ABSTRACT
The effect of an adventure sprint race (ASR) on T-cell proliferation, leukocyte count and muscle damage was evaluated. Seven young male runners completed an ASR in the region of Serra do Espinhaço, Brazil. The race induced a strong leukocytosis (6.22±2.04×103 cells/mm3 before vs 14.81±3.53×103 cells/mm3 after the race), marked by a significant increase of neutrophils and monocytes (P<0.05), but not total lymphocytes, CD3+CD4+ or CD3+CD8+ cells. However, the T-cell proliferative response to mitogenic stimulation was increased (P=0.025) after the race, which contradicted our hypothesis that ASR, as a high-demand competition, would inhibit T-cell proliferation. A positive correlation (P=0.03, r=0.79) was observed between the proliferative response of lymphocytes after the race and the time to complete the race, suggesting that the proliferative response was dependent on exercise intensity. Muscle damage was evident after the race by increased serum levels of aspartate amino transferase (24.99±8.30 vs 50.61±15.76 U/L, P=0.003). The results suggest that humoral factors and substances released by damaged muscle may be responsible for lymphocyte activation, which may be involved in muscle recovery and repair.
Subject(s)
Adult , Humans , Male , Cell Proliferation/physiology , Leukocytosis/immunology , Muscle, Skeletal/injuries , Physical Endurance/immunology , Running/injuries , T-Lymphocytes/immunology , Alanine Transaminase/blood , Aspartate Aminotransferases/blood , Flow Cytometry , Immunosuppression Therapy , Leukocyte Count , Leukocytosis/etiology , Monocytes/immunology , Muscle, Skeletal/immunology , Neutrophils/immunology , Physical Endurance/physiology , Running/physiology , T-Lymphocytes, Cytotoxic/physiology , T-Lymphocytes, Helper-Inducer/physiology , Time FactorsABSTRACT
Se presenta una serie de 5 casos con infecciones invasivas por S. pyogenes observados durante 1999, con el objetivo de ilustrar la diversidad clínica de estas infecciones. Todos los pacientes presentaron bacteremia y tenían condiciones mórbidas asociadas. Tres pacientes presentaron shock, dos de ellos de tipo tóxico y el mismo número de pacientes presentó manifestaciones cutáneas. Dos pacientes tuvieron alteraciones de coagulación. Todos los casos tenían leucocitosis (valor promedio 16800 por mm3) y aumento de la proteína C reactiva (300 mg/L en promedio). Los valores de desviación a izquierda y eritrosedimentación presentaron una amplia variación en sus resultados, observando pacientes con cifras normales. Cuatro pacientes recibieron tratamiento quirúrgico y 3 pacientes gamaglobulina endovenosa. Tres pacientes fallecieron (dos de ellos a las 72 horas). Los pacientes que sobrevivieron tuvieron una hospitalización prolongada que superó el mes de duración. Todos los aislamientos bacterianos portaban el gen que codifica por el superantígeno SpeA